Cytochemical Mechanisms of Penicillin Action

CYTOCHEMICAL MECHANISMS OF PENICILLIN ACTION VIII. : Involvement of Ribonucleic Acid Derivatives.

In a previous paper discussion was focused on the interference of penicillin with H transfer, although it was pointed out that phosphorylation and dephosphorylation resulting from the transfer of P04 are fundamentally as important as hydrogenation (Pratt and Dufrenoy, 1948). This paper describes the concomitant use of triphenyltetrazolium chloride (TPT), which deposits as a red formazan at site...

Cytochemical Interpretation of the Mechanism of Penicillin Action.

According to current usage, the term antibiotic designates a product of the metabolism of one micro6rganism that is antagonistic to the continuation of the normal life activities of another micro6rganism when present even in very low concentrations. Since the early literature on antibiosis has been covered extensively (4, 7, 29, 70, 71, 145, 190), we shall dispense with this phase of the subjec...

Kitz-Wilson Mechanisms of Action of Neostigmine and Penicillin

The molecular mechanism of penicillin action is closely analogous to that of neostigmine. Both drugs react covalently with the active-site serine of their target enzymes. In both cases, the susceptible enzymes self-catalyze their inactivation by their respective drugs. Kinetic analysis of cholinesterase by Richard J. Kitz and Irwin B. Wilson helped to establish that concept. Neostigmine and pen...

Mechanism of action of penicillin.

The Different Mechanisms of Action Potential Propagation in the Heart

It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...